main banner
You are here: Home page » Resources » References

Endocrine Society
Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement

2 February, 2009. Evanthia Diamanti-Kandarakis, Jean-Pierre Bourguignon, Linda C. Giudice, Russ Hauser, Gail S. Prins, Ana M. Soto, R. Thomas Zoeller, and Andrea C. Gore

Key Points

• An endocrine-disrupting substance is a compound, either natural or synthetic, which through environmental or inappropriate developmental exposures alters the hormonal and homeostatic systems that enable the organism to communicate with and respond to its environment.

• Issues key to understanding the mechanisms of action and consequences of exposure to endocrine disrupting chemicals include age at exposure, latency from exposure, the mixture of chemicals, dose-response dynamics, and long-term latent effects.

• Because of the shared properties of the chemicals and the similarities of the receptors and enzymes involved in the synthesis, release, and degradation of hormones, no endocrine system is immune to endocrine disrupting chemicals.

• Effects of endocrine disrupting chemicals may be transmitted to further generations through germline epigenetic modifications or from continued exposure of offspring to the environmental insult.

• The evidence for adverse reproductive outcomes (infertility, cancers, malformations) from exposure to endocrine disrupting chemicals is strong, and there is mounting evidence for effects on other endocrine systems, including thyroid, neuroendocrine, obesity and metabolism, and insulin and glucose homeostasis.

• The Precautionary Principle is key to enhancing endocrine and reproductive health, and should be used to inform decisions about exposure to, and risk from, potential endocrine disruptors.

• Scientific societies such as The Endocrine Society should partner with other organizations with the scientific and medical expertise to evaluate effects of endocrine disrupting chemicals in humans.

Download here

Last updated on 14 June 2011

About HEAL

The Health and Environment Alliance (HEAL) is a leading European not-for-profit organisation addressing how the environment affects health in the European Union (EU). We demonstrate how policy changes can help protect health and enhance people’s quality of life. Read more »

Members

HEAL has over 70 member organisations, representing health professionals, not-for-profit health insurers, doctors, nurses, cancer and asthma groups, citizens, women’s groups, youth groups, environmental NGOs, scientists and public health institutes. Members include international and Europe-wide organisations, as well as national and local groups. Read more »

Contact us

Health and Environment Alliance (HEAL)
28 Boulevard Charlemagne
B1000 Brussels, Belgium
Phone: +32 2 234 3640
Fax: +32 2 234 3649
E-mail: info@env-health.org
Press: Diana Smith

Direct telephone numbers: HEAL team page.

HEAL website privacy policy